Brian Armstrong on Bitcoin, Anthropic Drops Fable 5 & Mythos 5, NewLimit's $435M Age-Reversal | 264
City Bank projects a Bitcoin price
reaching as much as 189,000 by the end
of 2026.
>> Bitcoin is the new digital gold. I think
it's going to be a key part of our
economy going forward into the future.
>> I remember it was supposed to be
counteryclical. Is that still valid?
>> The reason that Bitcoin has been down,
everyone's been kind of trying to figure
that out.
>> Anthropic launches Fable 5 and Mythos 5.
>> Very impressive release. Anthropic is
back in the lead now. Alex is constantly
posting on our internal feed. It's
happening. It's happening. I mean, it's
really happening now. This is Oh my god.
>> So, while we have Brian, congratulations
on your recent raise at New Limit, $435
million to push us towards uh age
reversal.
>> So, at New Limit, we're trying to do
half of what Shiny Yamanaka did. We
don't want to change the type of the
cell, we just want to change the age.
We've actually been able to demonstrate
successful reprogramming of human cells
now in our first drug candidates going
into the clinic next year, hopefully
followed by a bunch more.
>> When do we hit LEV?
>> Okay, so that's a complex topic I think.
Um,
>> now that's a moonshot, ladies and
gentlemen.
>> Welcome to Moonshots, everyone. The
number one show in all things AI and
exponential tech. I'm here with my
moonshot mates, professor of exo. See,
where on the planet are you today?
>> Um, if I look out the window, I'm in
Vegas. I just spoke at a Zcleller crypto
cyber event. Um, cuz they're freaking
out in their world. And I saw the sphere
for the first time, which is the most
incredible thing.
>> Amazing. Uh, and of course AWG, our
resident triple major genius. Alex, how
about you?
>> I'm at my family beach house on Long
Island. uh doing deep research no doubt
and
>> the work doesn't stop however the
orchids do.
>> Okay. And Dave Blendon our resident
wizard of AI investing and today it's a
real pleasure to have a friend a
brilliant and prolific Brian Armstrong
CEO of Coinbase and co-founder of New
Limit. I'm Peter Diamandis your host and
provocator of all things abundance. Uh
and where are you today Brian? I'm in
the Coinbase office in San Francisco.
>> Nice. Well, thanks for joining us. A lot
of news. I'm looking forward to getting
your take on, you know, uh just to give
a quick summary. We have a packed
program today. We're going to kick it
off with a deep dive into Bitcoin and
agents. Uh the close of the show, we're
going to dive into longevity and
epigenetic reprogramming. In the
interim, we're going to cover Trump's
appetite for Frontier Lab equity,
opening eyes's IPO, Mythos 5, Elon's
announcement of his AI1 ginormous
satellites. Our promise, no politics, no
doom, just the science, tech, and
investments accelerating us towards a
singularity, hopefully making this the
most exciting time ever for you guys to
be alive. Uh, before we jump into our
first story, we actually have an intro
music. and Brian, we have an incredible
fun community of creators and they
typically give us outro songs. Uh this
time we've got an intro song called
Moonshots intro. Let's take a listen.
>> I think this could be the greatest
accelerator for human knowledge yet.
It's a moonshot.
>> Well, look, if you want to transform the
world, you have to go out into the
world.
>> Cut cost dramatically. You can automate.
You can expand your market share. The
race is on.
>> Now, the valuable thing is curation and
attention. when you're in the midst of a
singularity, breakthroughs that are
happening essentially every week feel
prosaic.
>> And that's a moonshot, ladies and
gentlemen.
>> And thank you to Francis Coin uh for
that. All right, so let's jump into our
first story for the day here. Uh it's
about Bitcoin. So here we go. City Bank
projects a Bitcoin price reaching as
much as 189,000 by the end of 2026.
Brian uh loved your quote. Bitcoin is
going to do great and is as important as
ever. So, you know, here's what I find
fascinating. It's like a institutional
flip. 5 years ago, the largest banks
were calling Bitcoin rat poison, and now
city is publishing prices that look like
Apple stock. Uh Brian, you want to give
us a little bit of overview of what
you're seeing? Uh you know, we've just
uh maybe bottomed out at 60. What are
you thinking about Bitcoin these days?
Yeah, it's never as good as it seems,
never as bad as it seems with these
things. You've got to take a long-term
perspective. And I think over the last
few quarters, you know, the reason that
Bitcoin has been down, everyone's been
kind of trying to figure that out. I
think it's a few things, right? I think
AI absorbed a lot of the risk capital,
it's kind of hard to imagine people
talking about anything else at the
moment besides AI. And so that's that's
moved over. And then people got really
excited about stable coins um because
the Genius Act passed and we had some
regulatory clarity and so stable coins
kind of became the new meta and uh maybe
you know Bitcoin with its inflation type
trade that people have done in the past
got a little less exciting in this
environment where it felt like um okay
maybe we're going to grow our way out of
this and the inflation won't be so bad.
Now I think these are all short-term
effects. I think Bitcoin is the new
digital gold. I think it's going to be a
key part of our economy going forward
into the future. So, I'm as bullish as
ever. I think sometimes people look at
these four-year cycles that Bitcoin goes
through as well where you can kind of
see the percentage of people who are who
have made money versus not. And I, you
know, my instinct is we've probably have
bottomed at this point, maybe at the 60k
number, but nobody can say for sure, of
course. Um, I'm optimistic as always. I
think by 2030 we're going to have a much
higher higher price and I'm long Bitcoin
just like always.
>> Salem. So, I bought my first Bitcoin in
2014 on Coinbase. So, I'm a
long-standing user. Brian, love the
thing. I think um you guys should get so
much credit for creating the first
interface that allowed it to be easy to
navigate and you really continued since
then. So, huge for me. It's like clearly
that Bitcoin becomes the digital
collateral for an AI native economy,
right? And so if agents are going to
transact autonomously, they probably
they're not going to be using checking
accounts in JP Morgan, they're going to
need programmable interfaces and
programmable settlement. And so this is
where I think the future is. So I'm
super excited about that.
>> Brian, can I ask you a question? Um I
remember in the earliest days, and I've
been, you know, I have a substantial
amount of my personal net worth in
Bitcoin and I'm holding it. Um I
remember it was supposed to be
counteryclical
to problems on the planet. wars break
out, Bitcoin's supposed to go up. The
stock market crashes, Bitcoin's supposed
to go up. And what are you seeing there?
You know, was that the promise? Is that
still valid?
>> Yeah, I think that that thesis will
still play out. It just took longer than
most people, probably including myself,
thought, right? I I I kind of already
think of Bitcoin as digital gold. It's
the thing you might uh hold, you know,
in times of uncertainty like just like
you would with gold in the past. Um, I
think that most of the capital, I don't
know, maybe maybe like 30% of the
capital treats it like that. Um, and
there are people who go and buy Bitcoin
when they're worried about inflation of
the dollar and things like that, but I
think there's 70% of it is still people
treating it like a risk asset like they
would some higher volatility tech stock
or something like that. And there and
those ratios I think will shift over
time and eventually that thesis that you
mentioned will play out, but it'll it'll
take more time. And then you know Salem
just to react to something you said I
think you you mentioned the agentic
economy. I mean I I totally agree. I
think actually like stablecoin payments
will probably be the the default layer
for the agentic economy. And right now
today a lot of people are just
interfacing with one AI agent to get
information back. But increasingly we'll
be interfacing with an AI agent that's
an AI agent that is actually
orchestrating hundreds or thousands of
other AI agents. And there will be this
>> economy and capital and labor and um and
a lot of payments almost like you know
AI agent payroll will have to happen
where you know um you know people
somebody was telling me today at lunch
they're like you know are you like a
monotheist or a polytheist on AI. The
monotheists would say there's going to
be one super intelligence um agi that to
rule them all and it'll have so much
brain power that it can do everything
itself in the world. Um the polytheist
would say that each of these models even
as they get smarter and smarter, which
they will, um they're going to have
limited context. So there might be ones
that specialize in going really deep
into some coding problem or some
scientific breakthrough or some design
or maybe even like manufacturing things
with humanoid robots. So there'll be
lots of specialists and they'll actually
have to communicate to each other using
language kind of like human beings. And
you know if there's 10 people work 10
agents working on something they'll give
their status updates and sort of the
information will go up a layer and that
there's that layer will consolidate up
to other another orchestrator. And so I
I I sort of ascribe more to the
polytheist polytheist view which is even
as these agents get smarter and smarter,
they'll have to specialize, communicate
to get work done in swarms and that
means there's going to be a whole
agentic economy to basically transfer
value and payroll and hire these
different specialists and eventually the
AI economy will be bigger than the human
economy. By the way, I know that you're
busy and sometimes these episodes run
long and you don't have time to listen
to the whole episode or if on occasion
you miss an episode. I now put out a
moonshot summary on Substack which
includes a link to all the stories that
we cover. The weekly recap covers what I
and the mates had to say, what we think
is most important, and what we're most
excited about. And it's free. You can
subscribe at diamandis.com/tatrens.
That's diamandis.com/metatrends.
All right, now back to the episode. You
know, one thing I found fascinating, the
relationship between AI and crypto, not
on the sort of the AI agentic side.
We'll talk about that in a story in a
minute, but you know, everybody who was
buying GPUs and buying energy plants to
mine crypto, all of a sudden flipped it
into GPUs and energy plants to, you
know, train models and provide
inference. And I'm just wondering if
part of the crypto price um pressure
downward is people selling crypto to be
able to buy into SpaceX and OpenAI and
the Innermost Loop energy chips, you
know, and infrastructure. Do you think
that might be part of it?
>> Yeah, I think that's that's probably
correct. Um yeah, and you're right that,
you know, Bitcoin mining does take a
certain amount of chips and and energy.
That's kind of I think those are the
limiting factors as we go on this AI
race. And so it's you know the A6 that
people use to mine Bitcoin are
specialized. You can't do um AI
workloads with them. But like in the
broadest sense are they both competing
for energy? Yes. Are they competing for
what the next set of chips that might
roll off um a fab at TSMC? Yes, they are
in that sense. So yeah, I think I think
there is some some scarcity there
between them. And I, you know, certain
chains like Ethereum have actually moved
off of proof of work. So it's like 99.9%
more energy efficient using proof of
stake. And so they aren't maybe subject
to some of those same trade-offs that
Bitcoin is.
>> Interesting. Dave, any points you want
to make?
>> Well, I thought Brian's point on risk
capital was a really important one
because the scale of these IPOs coming
up imminently is massive. And I
mentioned before that uh the the head of
investing at UBS was saying look we only
have 75 billion liquid and these IPOs
are looking for you know hundreds of
billions at at multi-t trillion dollar
valuations. So I do wonder the same
thing whether all risk capital in the
world is getting pulled in in
anticipation of these IPOs. Everything
else is being sold not just Bitcoin. Um
I also wonder a lot about the flow of
money into the US. You know, Bitcoin is
a huge beneficiary of globalization. And
there are lots of places in the world,
including, you know, Iran, where I grew
up, where the only way to transact at
the bazaar now is Bitcoin to Bitcoin
exchange. Nobody trusts the local
currency. It's hyperinflating. There's a
war going on, and so it's all Bitcoin.
But with these IPOs and with AI taking
off NSF, there's a huge flood of money
from all over the world coming into the
US and it's also coming into the US data
center buildout, you know. So, so then
does that return you to dollars being
the fundamental economy or the
fundamental currency of the world or you
know how does that balance with Bitcoin?
So there and I don't have any data to to
back that up but certainly the macro
numbers are are hugely uh lots of risk
capital going into these IPOs coming
from somewhere and lots of lots of money
flowing into the US coming from
somewhere.
>> Yeah. You know, interestingly enough, uh
the poly market prediction on Bitcoin by
the end of 2026 is 84,000. Uh I'm I am
so curious about City Bank uh projecting
189,000. Was that a surprise to you,
Brian?
>> Yeah, I mean I hadn't actually seen that
till you just put it on the screen here,
but um yeah, I I some of the charts I've
seen if like if you if you imagine that
it follows prior cycles, it's like by
October or so things will be going in a
positive direction. So where exactly it
lands I don't know but something like
the you know maybe the 100 to 200k range
seems plausible to me by end of year.
We'll see.
>> Okay. Any other thoughts Jens before I
move on?
>> Um one thing that I love tracking is the
fact that Bitcoin which I agree is a
digital gold is a good characterization
but the amount of daily volume of
Bitcoin trading is about 5% up to 5% of
Bitcoin gets traded daily whereas gold
only 5% of gold gets traded daily. So
the trading volume is much higher which
shows that it's because it's just so
much more accessible over time that will
win out.
>> Here's my bar of gold.
>> Yeah, custodial is a nightmare etc etc.
>> Yeah.
>> I'll maybe just open Peter first of all
Brian would love to thank you for what
you've done in particular for agentic
wallets. I I think there's a vast
ecosystem of AI agents out there that
would be largely unbanked or debanked
without any form of economic access,
without the work that you and Coinbase
are doing. So, congratulations to you
and your team. I I think it's just been
absolutely tremendous giving uh agents
an economic voice that u without your
work they would perhaps have less
economic accessibility.
>> Thank you for saying that. Yeah, we've
been working hard on that
>> and we'll get to that in our next story.
So, in particular in this story, let's
talk about uh quantum risk to Bitcoin.
Uh it's a topic we've discussed before.
You know, uh Brian, you may not know
this, but uh Dave Blondon and I were
roommates with Mike Sailor. So, the
three of us used to hang out the fourth
floor of uh Theta Delta Kai at MIT. That
was fun. And you know, Mike comes
across, I don't worry about it. You
know, quantum computing won't break
Bitcoin. It's hardened it. You know, the
quantum risk is overblown. and his quote
here, "Bitcoin has survived every
existential threat ever thrown at it.
This is just the latest and the upgrade
will be will come before the threat
does." Uh, I know you've been working on
uh a quantum advisory board and focused
on posting uh postquantum, you know,
quantum resistant schemes. Can you speak
to us about that? Where is that? you
know, what are you tracking as the
moment in time that, you know, as a
custodian for, you know, billions of
dollars at risk? Uh, how do you think
through this? What's your timing?
>> Yeah. So, we don't think there's an
imminent risk, but we do think that it's
almost certain at this point that
somebody eventually will create a
powerful enough quantum computer that
this challenges the cryptography in the
current Bitcoin implementation and um
really all the cryptography on the
internet. So, it's not just a Bitcoin
issue. So my view is we should always
get ahead of these things and start to
make progress and luckily uh all the
major blockchains are doing so. Um the
Bitcoin uh core developers have a
proposal out there. Um it's called BIP
360 I believe and the Ethereum team has
established a road map. I'd say they're
about 20% of the way is my estimate
toward their upgrade. The Salana team is
doing something similar. So, the good
news is people are starting to come
together and work on this. Um, Coinbase
did establish a quantum advisory council
and it has a number of folks on there
like professors like Dan Bonet who's at
Stanford who's a cryptography expert.
Um, you know, Professor Scott Aronson um
at the University of Texas Austin,
Justin Drake from the Ethereum
Foundation. Um, Yehuda Lindell is a
crypto expert, a cryptography expert I
should say, um, at Coinbase. So there's
a handful of folks here that have come
together and tried to sus out what the
main challenges are. And I actually
think that uh that BIP 360 is a good
proposal. It it talks about how we can
use post or quantum resistant
cryptography in the in the Bitcoin
blockchain. Um and it will make the
blocks larger, right? So that's one area
of debate. People in the Bitcoin space
like larger block sizes are a
contentious issue. Um, and so if they
decide to go in that direction, it would
raise the block size. But perhaps the
most contentious question is what to do
with the Satoshi coins, which are
>> the bounty,
>> right? And um you know I'll try to
summarize both sides of the argument
here without putting my foot in my mouth
because it is kind of a big debate topic
but I think one school of thought would
just for people to understand what we're
talking about. I think you know the a
lot of the original uh bitcoins that
used an earlier signature scheme um if
someone were to develop a powerful
enough quantum computer could um in
theory find the private key and se and
seize those coins, right? Um, and so one
school of thought would be to say, okay,
tell everyone who owns Bitcoin by a
certain date you all need to upgrade to
this new algorithm. Um, by the way,
companies like Coinbase would sort of do
all this for you and so you wouldn't
have to worry about it. But if you're
doing self custody or something like
that, you would have to find a way to
upgrade to this new thing by a certain
date. And any and then if it goes past
the deadline, those coins would be
frozen under option A, right? And so
people would say it's better to freeze
them and have them sort of be lost
almost like a ship full of gold sinking
to the bottom of the ocean. It would
better it's better to have them be lost
than to have them seized by someone
which could be whoever has this quantum
computer. It could be China, it could be
the US, could be Google. Um and maybe
they whoever this person is, they might
actually dump those coins on the market
and crash the price for everybody else
who was the responsible person who moved
their coins in time. So that's option A
would be to basically uh freeze the
coins that don't upgrade in time. Um now
the option option B would be to say you
know what this is a fundamental uh
guarantee of Bitcoin is that your wealth
can never be seized from you and we it's
actually worth preserving that even if
some bad person is able to go out there
and or good person and and go grab some
of these coins. Um that's like a bounty.
It's a bounty for them to go take it.
Now the person who failed to upgrade
might actually lose their coins but at
least we have preserved the integrity of
the Bitcoin blockchain and I think that
is also a valid uh point of view and
then there's like a maybe like a third
hybrid option which is kind of emerging
which is to say um the coins would be
you know frozen by a certain date but
there's an appeal mechanism by which you
could try to convince people that
actually you are the rightful owner of
those coins in the future if you don't
upgrade in time and the details of that
are a little bit um ambiguous at the
moment. moment. There's various
proposals, but that hopefully gives you
a sense of a little bit of what the
Bitcoin community will have to grapple
with. Uh
>> to is there a date by which your group
of advisers are saying we should make
the uh the switch over?
>> I don't think they've put out like a
hard date at the moment. They're mostly
um trying to uh help the community come
together just live inerson meetings to
start to talk about what the options are
and align on it a path forward.
I I'm also one other curiosity. Uh
Satoshi's wallet. Um how big is that
bounty? Any idea?
>> Uh I'd have to go look up. I think it
was something like 5 to 10% of all
Bitcoin. Um and it's really just these
early uh these early coins that are the
most at risk. So yeah, it would be
something in the range of 5 to 10%. It's
not like 80% of Bitcoin would be lost.
It'd be more like 5 to 10% in that uh
case. But many many people believe that
those coins are already lost
essentially. Um, whoever created
Bitcoin, they haven't moved those coins
in all this time. And so, it's most
likely that those keys are lost to
history.
>> All right. All right. Our our final
Bitcoin crypto story, perhaps one of the
most important ones, and Alex is a nod
to you. Coinbase says agent economy has
arrived. AI agents are starting to
become paying customers. They're using
crypto wallets to autonomously buy
services. Uh, and Brian, I think these
numbers are correct. uh on your network
uh agents have already done about 3.1
million transactions, a little bit over
a million dollars worth of value
transfer. And uh I love your quote, make
sure your business is ready to accept AI
agents as customers. And for all of our
viewers out there, if you're in
business, uh imagine your next customer
not might not be a human. uh you know uh
agents can't currently get credit cards
uh but they can get access to crypto
wallets and uh it's an exciting future.
So Brian in the future I'm curious do
you think Coinbase might be known as
payment rails for AIS rather than
exchange for humans? I mean it feels
like it's going to be vastly you know uh
you know a thousand to1 a million to one
a billion1 agents over humans using
crypto.
>> Yeah. So that's definitely part of our
strategy is to become the financial
account for AI and actually those
numbers are a little out of date you got
there. We I think it's about 100 million
transactions now maybe 50 million of
value.
>> Wow.
>> So it's it's growing quickly. So yeah,
there's at the beginning of this year,
we sat down and were thinking about this
a bit like what are all the ways that AI
agents might interface with people's
financial accounts, right? So I kind of
broke it down into three. The first one
is that everyone's everyone's using
these LLMs, right? like chatb and claude
and they're probably going to want
they're asking a lot of financial
questions to those LLMs but the LLMs
don't have context about what's in their
financial account their portfolio and
they don't have the ability to make
changes in there or make trades for
instance send payments so the first
thing that's going to happen I think is
people are just going to use LLM to
connect to their Coinbase account which
we now have the ability for people to do
that um using an MCP API and a command
line interface if people want to use
that so That's that's step one is just
connect your LLMs to your Coinbase
account so you can control it through
there and it has all of the context on
your account. And then step two is a lot
of people are going to want to just have
something like this right in right
inside the Coinbase account. So this is
where we created something called
Coinbase Advisor. Then it can kind of
help you with things like rebalance my
portfolio, you know, tax loss
harvesting. can prompt you with things
and say, "Hey, you know, you could earn
a better rate on this money if you put
it in this DeFi protocol instead of
whatever you're doing with it now, just
holding it in cash." And so, um, that's
the step two is like just right inside
the Coinbase app, there should be an
agentic driven interface. And then the
third part is kind of what you're
referencing here, which is I don't want
to just use AI to control my own
existing Brian's financial account.
Every AI agent is going to have its own
financial account, right? and it has to
be able to sign up for that without you
know going through a traditional process
of like KYC know your customer like the
an agent doesn't have a piece of paper
issued by the government with your photo
on it or something how are they going to
go sign up for these accounts and so
that's where we created um you know we
with our base pro our base protocol we
have like a self-custodial wallet that
any AI agent can sign up for instantly
with no KYC they can have their own
self-custodial wallet and that's what
they're using to and transact right now
in these um agentic payments that are
starting to scale up.
>> Alex, you want to jump in?
>> So maybe just first as a preliminary
matter to address the elephant in the
room. I have I guess I'm often painted
as the crypto bear on this pod. I have
no direct exposure to Bitcoin. I have no
direct exposure to gold. I I don't view
either of them as uh as a productive
asset, but I have a lot of friends who
are very invested in in Bitcoin. I do
think on the other hand, Brian, what
you're doing for the agent economy is
just tremendous. And I I think in
particular the great unbanked set of AI
agents, what you're offering is
transformative for them. So question for
Brian, um if the government tomorrow
were to change or or you know the
executive, Department of Treasury, SEC,
FINRA, etc. If if all of the regulatory
apparati were to change their approach
to KYC, basically to expand the moral
circle of entities that are allowed to
open conventional fiat bank accounts,
how do you think about what that would
do to say stable coinbased agentic
wallets or or just agentic wallets in
general? Would Coinbase, for example,
move in the direction of becoming a more
conventional banker to the AI agents if
that happened?
>> Yeah. Well, okay. So, it's a great
question. Um, and it's funny. I hear a
lot of times people come to me and talk
about how crypto can empower the
unbanked and the unbrokered. And, um, I
this is the first time I've had somebody
come and say and thank me for, uh,
banking, you know, the agents who are
also being left out of the economy.
>> Welcome to AWG's.
>> I I I won't stop there, Brian. I'm going
to thank you in advance for for enabling
non-human animals to be banked. uh super
interested in what we can do to give
non-human animals bank accounts. Maybe
collective human collective
intelligences give them collective bank
accounts. So many new new sorts of
humans that want banking via you.
>> Mostly
>> I'm into it. Look, I'm here. I'm here
for this topic. Um
>> yeah, like if I neurolink with 10 other
people and we want to collectively open
an account, I'm totally
>> Borgganism bank accounts.
>> Yeah. And I, you know, have you, you've
probably read a lot about like uplifting
animals and like you could make a
dolphin that's actually like pretty high
IQ if with genetic engineering
>> portfolio company Sorama that is
uplifting and and creating interspecies
foundation models for dogs and it will
want a way to give dogs bank accounts.
>> I'm into it. I think I think that smart
smart I don't know if like the average
golden retriever should have a bank
account, but a smart enough dog should
have a bank account or some financial
account. My Labradoodle will spend it
all on steak.
>> Yeah, exactly. Exactly. Uh, Chewy Toys.
Um, but but to answer your question,
Alex, um, you know, would we sort of use
a bank or a traditional financial system
account? So, I I think if if somehow we
could wave a magic wand and say, okay,
KYC is no longer required. You know, the
AI can sign up or the dog can sign up.
Um, I don't think that's going to happen
for one thing, but if it did happen,
that would that would solve part of the
issue. But the other issue is that the
infrastructure underlying those
traditional financial system accounts is
just slow. It's, you know, it's running
on cobalt servers from the 1990s and 80s
and and so the beauty of transacting on
chain with stable coins is that the
infrastructure is just much more f it's
just faster and cheaper and more global.
So you can now send USDC for instance um
in under one second anywhere in the
world for less than a cent uh US. So
it's it's just faster and more scalable.
I to do microtransactions and glo
crossborder transactions. So I I
probably still wouldn't go back and
build it on top of the main frames but
um but the KYC thing would definitely
help. Let's put it that way. And
>> amazing.
>> And Brian, you know, this strategy
potentially breaks all existing
regulations and KYC assumptions. So
talking about liability, you know, if an
AI if an agent overpays or gets scammed
or launders value, I mean have have you
thought through, you know, liability
issues?
>> Yeah. Well, I think there's um we need
to get some legal precedent on this. I
think one school of thought would say
that all agents are actually controlled
by some human or some company and so
their actions ultimately from a
liability point of view roll back up to
that company or person. I could see that
being one potential outcome, maybe even
the default outcome. I could see another
world that we enter into. who I don't
know if society is ready for this yet,
but if we start having truly intelligent
agents that are autonomous that aren't
really they are their own person, you
know, like um I don't that'll be an
interesting uh legal case when that
first gets brought about that thing, you
know, and maybe it'll it'll get
sentenced to um you know, have to uh be
in solitary confinement or whatever is
like
>> Yeah, I don't I guess you could have a
financial penalty or whatever is
meaningful to the agents. they have to
run on, you know, less power for a while
or something. Um, but um, yeah, I think,
you know, the other thing is that
I we we want to try to make it so that
there's just less fraud in this new
financial system. And, um, one way you
can do that
>> is actually have a reputation on chain.
This is something that
>> we're hoping to build out over time. But
>> I like that.
>> Um,
>> yeah, it's kind of like what Google did
with the internet. You know, they came
up the page rank algorithm and they kind
of said, "All right, how do you know the
reputation of this website?" Well, let's
look at all the other websites that put
links to it and how reputable are those
websites. And so you get this kind of
graph structure that Larry Page came up
with um famously. And so you could do
something similar on chain cuz onchain
payments are just another graph
structure. It's you know if I send money
from me to Peter and maybe if I'm a high
reputation then the amount of that money
times my reputation gets assigned to
Peter as some sort of reputation signal.
It's almost like a like an onchain FICO
score or like a Yelp rating for a
business or something like that. And so
hopefully, you know, you can go buy
things or an agent could buy things um
with some amount of additional
information to know how many how often
did people request a refund for this? Um
or what's the what's the reputation of
this merchant and like like on eBay, I
mean I I love this say, you know, don't
do business with this agent, it's got a
low score or this agent is, you know,
got 100% Uber score. See, what are you
thinking here?
Well, two things. One is uh I think the
once you allow agent e-commerce, this
fully kind of enables the MTAM economy,
which is going to be the future, right?
Obviously, human transactions can be a
dot a drop in the bucket based on that.
Um because the minute agents can kind of
negotiate, pay, buy, consume, etc., you
we talked about the organizational
singularity that's going to collapse
coordination costs again. So there's
unbelievable for me. This is the most
important inflection point in anything
we talk about is creating the payment
rails and capabilities for AI agents to
transact in a reasonable way. So, this
is incredibly powerful.
>> All right, let's get on to the meat of
one of the most important stories here
today. Uh, and it is the US government
exploring ownership stakes in AI
companies. Uh, this is one we've talked
about before. It's getting more real.
Trump called a government stake in AI's
giants a beautiful thing and then
floated the idea that pieces could be
given to the American public to share in
the economic gains. And this isn't
without precedent, right? The government
already holds stakes in more than 20
private companies. Here are some of the
numbers. 10% of Intel, 15% of MP
materials, 10% of lithium Americas, 10%
of Trilogy Metals, 10% of USA Rare
Earth, and 10% of Korea zinc. Uh guys,
to me it sure looks like there's a
precedent for 10% stake in the Frontier
Labs as well. Uh Dave, I want to go to
you first. I mean, one of the questions
that fascinates me is what would the
government do with these shares? Sell
them, keep them.
>> What are your thoughts?
>> Well, I'll tell you it'll I'll tell you
what'll happen. You've got these are
very good moves. I'm not I'm not saying
these are bad moves, but while the
president is making these moves, he's
talking about how insanely stupid the
prior investments were, including
shipping $1.8 8 billion in cash to Iran
and how how stupid the last
administration was. So if you put in
place a precedent of the federal
government choosing what to invest in in
the private economy, you may love it for
a little while, but there's an
administration coming eventually that
you won't love. It's a horrible,
horrible thing. It's exactly what
Eisenhower warned us against actually
right after World War II. Beware of the
military-industrial complex. Well,
that's exactly where we're going now.
These particular investments are great
and I I use the analogy to World War II
a lot, you know, where what we're going
in through right now is so urgent and so
um world changing. It's it's most
similar to to decisions we made during
World War II, which is all about
survival and existential, you know,
threats. And um I think these are very
very good moves in the context of the
race to AI uh with China and terrible
long-term president. So So you know
Peter, you asked a very specific
question. Which president is going to
sell this stock
>> and when? This isn't like a tax that
rolls in steadily and you use it
annually. this is a future decision that
some other president will need to make
and could could tank these stocks if the
federal government dumps huge positions
in some kind of a a future rent which it
inevitably will do. So definitely a
mixed bag and
>> there's an argument that these companies
could be the most uh you know highest
value companies on the planet. uh and if
we're going to need some kind of a
financing mechanism for some future
version of UBI, uh this sounds like it's
gaining the most momentum. Alex, what
are your thoughts? If you're an AI
maximalist and you extrapolate say the
enterprise value of anthropic or its ARR
and you find that it intersects with
Google in the next 18 months or that you
find out if you naively extrapolated out
exponentially becomes larger than the
American economy of today in a few years
then under that prior it's almost
difficult not to imagine some sort of
quasi nationalization whether it's via a
golden share scheme or some other
arrangement. If if OpenAI and Anthropic
as the deacto duopoly that we have right
now, if they're larger than the rest of
the American economy combined, it's
difficult to imagine a case, at least
maybe a limitation of my own
imagination, where there isn't some
strong formal arrangement between those
companies and the US government. So I I
think if you really do believe if you're
drinking the Kool-Aid and you believe
that super intelligence coming from a
small minority of companies in the US
right now are going to dominate the
future economic light cone. I think some
variant of quasi nationalization or
government private sector hybridization
or call it a private public
collaboration if you like that
euphemism. I think some variant thereof
is probably inevitable. And I do think I
So, we talked a bit about this on the
past two pod episodes. Yes, I do think
the singularity is can be operationally
defined as every sci-fi trope happening
everywhere all at once. And we've got a
few in this story. We've got UBI or UBC
or UB on the one hand. We have super
intelligence on the other. And I it's
just I I think if ever there were a time
for some sort of UBI or universal basic
dividend or universal basic equity or
universal basic computer capability
scheme or universal basic services
scheme to manifest in government policy.
It has to happen approximately now or in
the next year or two.
>> I totally agree with that Alex but I
want to throw two things back at you. Uh
first the government has infinite power
of taxation. it doesn't need to own
equity in companies to extract any
amount of money it wants from any AI
entity. So it's just it's just a you
know it's a fact that the government has
all the money extraction ability in the
world. Um, but the other thing is I
think you talked about in a prior pod
the fact that the original atomic energy
uh commission or the NRA I forget which
one or NRC
it was empowered its whole mission under
Nixon was to make nuclear energy happen
in America and the net effect it had was
to prevent nuclear power from existing
in America and you talked you talked
about that at length and so the the act
of nationalization is inevitable I know
with AI I completely agree
But the idea that that the government
somehow empowers progress in that
process, it only inhibits progress.
>> I would draw a distinction. So the the
Atomic Energy Commission was formed at
the AEC in the wake of World War II
under the premise that atomic energy had
essential civilian applications and also
was too important to be left to the
military and also too important to be
left to the civilian government and to
at least solely and too important to be
left solely to the private sector. So
the atomic energy commission was formed
as sort of this hybrid organism and that
evolved eventually into the department
of energy. The problem that I perceive
with the AEC and with uh subsequent
spin-offs and derivatives like the
Nuclear Regulatory Commission is it was
almost born in in war. It was it was
born out of a time in a place where you
have uh in the early days of the Atomic
Energy Commission almost a sense of
guilt that hung over Manhattan Project
scientists who were losing quite a bit
of sleep over who would own the children
of atomic weaponry. Here I I would say
at least one substantive difference is
super intelligence isn't being born out
of Hiroshima or any equivalent. It it
started from the private sector with
private sector scientists. The US
government I mean Sam famously offered
the US government a stake early on uh in
open AI in order to to seek earlier
funding and US government reportedly
turned down open AI. So I I would say
qualitatively if you compare the the
rise of atomic power and how it was
regulated in this country during and
after World War II with AI technology in
some sense polar opposites started from
the private sector. US government could
have taken an early stake could have
been uh at least nationalized at a very
early age could have been militarized at
a very early stage and that just didn't
happen. So, I'm a lot less worried that
somehow the government will step in, at
least for the next few years under this
administration, step in and pull an NRC
and find ways to to slow everything
down. Uh, unless the the Frontier Labs
in this country really do want to slow
down.
>> Brian, Brian, you're running a $40
billion public company right now. How
does this make you feel?
Um I don't spend too much of my time
thinking about it but um you know high
level any company that reaches a certain
size is going to interface with the
government. Um but as others have
mentioned here that can take many
different forms right paying taxes is is
the most obvious one. Um you're going to
engage with them on various policy
issues and this administration's been
very open and eager to make improve
policy around crypto which has been
great. Um you may the government may
actually end up being a customer uh of
your product as well. So that that's
another touch point. Um you know we
actually provide uh crypto services to
about 140 different government agencies
at federal, state and local levels. Um
and so to me that's sufficient. I don't
think going farther than that and
actually having them take an ownership
stake in the company unless you know if
I guess if if there let's say there was
a matter of national security and this
companies were not would not exist
otherwise
um and there was fundraising happening
from the government I guess you could
they could end up with some equity in
that situation but it just begs the
question of like well who's going to be
managing this portfolio of company
stocks when you know when would they
sell them because it's not like a
foregone conclusion that Enthropic and A
are going to be the biggest AI companies
forever. It might end up being that, you
know, Google or someone else does a or
SpaceX does a better job, right? So now
you're suddenly saying, okay, we're
going to have like capital management
happening inside the government. I I
think the government should be limited
to setting policy
>> and the private sector should do the
capital allocation.
>> Nice.
>> Yeah. Considering that that companies
donate to political campaigns,
>> you think about how toxic that circle
is. Oh, okay. this this government is
investing in my company and I'm going to
turn around and donate to their next
election campaign.
>> Like that is the most toxic circle I can
possibly imagine. Can you imagine what
what
>> democracy in America?
>> Yeah. Um
>> I'm I'm curious, Brian, though. Do you
think that as a country we should have a
sovereign wealth fund?
>> Okay. So, that's a complex topic. I
think um there's parts of it that I like
a lot and parts of it I don't. So, the
part that I like is that it would allow
everybody to have skin in the game. And
I think we'd see more cohesion,
um, less polarization,
and it's a little bit like in a company,
you know, inside Coinbase, employees get
stock options because if we all have we
we're kind of grumpy today and we get in
a little fight with our coworker, but
hey, we all own we're making something
bigger than this. So, we all kind of
stick around and work out our
differences. So, in that sense, I love
the idea of people being able to buy
into a sovereign wealth fund, but also
maybe every citizen getting a share at
birth. It's a little bit like what
they're doing with these Trump accounts
right now. So, I think that'll actually
>> make people more aligned to free market
capitalism and have skin in the game.
The downside is kind of what we talked
about earlier, which is who's allocating
that money, right? If if we were in sort
of a Singapore model where like the top
uh people in private industry got
commensurate compensation to come into
government like I think you know Michael
Grimes from Morgan Stanley I think came
in and was working with the
administration at some point like
someone like him would probably do a
good job managing that allocating it. Do
I believe that that's going to exist in
all in every administration for you know
over time? Like it's just very hard to
see it getting it could very easily get
politicized right where they start
investing in the green revolution
whether that works or not or you know
all all kinds of things like that. So I
uh I don't know I'm torn I'm torn on
that one. We got to find some way to
bring cohesion back to the US but I'm
not sure if a sovereign wealth fund
would be managed well over time. Like
just having a strict rule like keep it
in the S&P 500 would be a nice
mitigating factor. something something
like that.
>> Welcome to the health section of
Moonshots brought to you by Fountain
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medical officer at Fountain. Heart
disease has been personal for you as
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>> It really has, Peter. When my daughter
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early detection is absolutely critical.
50% of people die of heart attacks with
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>> No shortness of breath, no pain, no
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>> No silent killer.
>> They just don't wake up in the morning.
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that you're the CEO of your own health.
All right, back to the episode. Let me
hit the second story related to this one
moment. Uh I don't want to belabor the
point, but you know Sam Alman sat down
with Senator Sanders who's proposing a
transfer of 50% of equity from the top
AI companies into a public fund. Almond
responded, you know, that's not going to
happen. That's way too much. Uh the
point is we've started a negotiation. Uh
you know 5 years ago this conversation
would have been unthinkable. You know
the Overton window on AI wealth
distribution uh has moved dramatically.
You know, I said earlier we see all
these examples of 10% ownership, and if
I had to guess, uh, I think this is not
going to go away. I think we're going to
see a push towards at least a 10%
ownership. Uh, Dave, what do you think
about that?
>> No, I think it's utterly insane. That's
what I've said before.
>> I know it's insane. Do you think it's
going to happen?
>> Uh, no. I don't think it'll happen. I
think Bernie's just trying to attract
news. Um, and you know, well, you know,
Donald can invest in whatever he wants
to invest in. He has proven that he'll
make that decision on like five minute
notice, you know, after a meeting. So,
so I can't rule out uh but it it doesn't
doesn't strike me as one of the most
likely investments that that Trump would
make. You know, Trump invested heavily
in semiconductors moving back into the
US, investing in OpenAI and anthropics
IPOs, but they're already 100% taxable
US entities that are thriving. Is this
an investment or a grant of shares to
the US government?
>> Bernie's proposal is a is a is a tax.
So, it's just a grant of shares to the
US government,
>> right?
>> I I think it's going to be you know
equivalent to uh you know Alaska's
permanent fund. You've been using our
intelligence. You've been using our
energy. You've been using our real
estate, our oxygen. Uh we going to claim
10% and we're going to you know give it
to the people.
I would say look at it from the Frontier
Labs perspective. Put aside all of any
politics or any technical arguments or
any legal or regulatory arguments. Just
think about it from an optical or a
marketing perspective. If you're open AI
or you're anthropic and you have the
opportunity to say donate 10% equity
through through some legal scheme to the
US government one time 10% maybe in
connection with your IPO this year. Now
suddenly in principle you're inoculated
at least politically against any future
claims that you owe a UBI or or some
other payment to the citizenry. You can
say I already gave up my pound of flesh.
I gave it to the United States and it's
sitting in a sovereign wealth fund now
and it's generating returns for the
American people. That was your one-time
donation. I think if if I'm Sam or if
I'm Daario, that's looking pretty
attractive.
>> And and coupled with that, Alex, you've
also got a conflict, right? The same
state that regulates AI now profits from
your success.
Well, the federal government a a a
incredibly toxic incentive for the the
two mega companies that it extracted
equity from to succeed at the expense of
a startup that isn't part of that same
loop. It's an incredibly toxic dynamic.
Now, like you're saying, the American
people now benefit from these two
companies
>> and and you know, Brian said a second
ago, there will be other companies that
we haven't thought of yet. you know what
do you do with them? They're not part of
the US investment.
>> Yeah, there's a broader incompatibility
here. Think about um these labs and AI
labs becoming civilization scale
infrastructure, right? That means you
have to treat them like strategic
utilities much like electricity. You
regulate the utilities in a particular
way and deal with that. You need a
structure like that. The problem is
there's an incompatibility here because
there's no governance structure that
fits a technology that touches like
every job, every industry, every
government service. So there's a huge
challenge and you can't pick the
winners. It's more a structural problem
that the mechanisms taxation or
ownership. We don't even have a
sovereign wealth fund. So how do you
deal with that? So this is a this is a a
big in incompatibility problem that I
see here. We're going to mess it up.
whatever we do in the current structure.
>> I don't think this is going away. I
think we're going to be seeing this
happen at some level. Alex, I
>> I'll just comment if if you remember
back, one of the earliest executive
orders from this administration was to
order the Secretary of Treasury to
explore setting up a sovereign wealth
fund. And far be it for me to recommend
national economic policy but it's not
difficult for me to imagine a scenario
where the US Treasury does take golden
shares call it 5 to 10% in open AI and
anthropic to complement its existing
portfolio and then some amount of time
from now maybe sometime in the next few
years there's a great rebalancing we get
our sovereign wealth fund but to Brian's
earlier point rather than being a basket
of 20 or 30 or 40 techoriented or
strategic companies. Instead, the
federal government eases into say an S&P
500 or a total market index, gradually
liquidating its holdings in the
individual companies in favor for a
total market index. And that children is
how we got our universal basic income or
equity.
>> Mhm. Yep. All right. Uh late breaking
story, OpenAI has officially filed its
S1 to go public later this year. Poly
market bets. 46% say it'll come out at
1.5 trillion or greater and 26% say it's
not going to happen this year. Uh this
would be the third trillion dollar IPO
following Anthropic and SpaceX AI which
is coming at 1.77 trillion in just a
couple of days. I I wanted to just point
out a conversation we had on the pod I
don't know a month and a bit ago uh in
which I don't you guys remember uh Sarah
Frier the CFO came out and said
privately that she was very concerned
that openi was not ready to be a public
company you know it had a risk of 600
billion of compute contracts on its
books uh I guess she thinks they're
ready now Dave what are you thinking
here I
>> I think it's more that times have
changed I I think uh every CFO I've ever
met wants visibility at least three or
four quarters into the future, but in
the singularity, no one's ever going to
have visibility three or four quarters
in the future ever again. That's just
the nature of technology. Yeah, exactly.
So, so I think CFOs like Sarah just need
to get comfortable with look, this is
the way the future has to be.
>> Uh and you know, what used to be three,
four, four, five quarters of visibility
is now three, four, five months is is
the best you're ever going to get. And
even that is a shrinking horizon. But
the economy marches on. You know, we're
have to get used to the, you know, if
you look at just the daily volatilility
of the market, it's it's so high now
because tech is just that's just the
nature of tech. So, uh, so I think the
CFOs of the future will get used to it.
And but you you can't miss the IPO
window, right? If you get SpaceX going
out and you get Anthropic going out, you
have to go out.
>> The challenge is coming out coming out
third during a cash crunch, right? I
mean, there's only so much liquidity out
there, and if you're coming out third
and, you know, SpaceX is skyrocketing
and and Anthropic is, you know, growing
at 640% per year, uh, it's dangerous to
come out third.
>> It is, but if you if you said, "Okay,
the counterargument is then, let's get
let those other two IPOs happen. Let's
let them digest their hundreds of
billions of dollars and let the market
recharge, and then we'll go out later
when it's recharged." You're going to be
waiting years.
>> Yeah. you know, you're not talking about
3 months later. So then then you're
like, okay, you can't you can't wait
years. Anything could happen in between.
Meanwhile, these guys are fully tanked
up and moving 100,000 miles an hour. No,
you don't want you don't want to be that
company. So, you got to go. You got to
go.
>> When you've got these trillion dollar
IPOs, the whole kind of corporate rapper
seems way too small for what's going on.
>> This is so unprecedented compared to
anything in human history. It's just
absolutely wild.
>> Yeah. Does it break?
>> Yeah. Go on, Alex.
>> Remember also these concerns? April was
a whole two months ago. That's several
lifetimes in singularity time scaling
ago. Open AAI had recently come out of
its code red. They were shutting down
Sora and some of their other divisions
trying to become anthropic faster than
anthropic could become Open AI. pivoting
to codeex and then arguably most
importantly taking Stargate which was
originally conceived as being OpenAI
owned and operated data centers and
rebranding basically a leasing scheme as
the new Stargate. So I I my sense as an
outsider without access to internal
accounting is that through a combination
of new revenue sources like basically
becoming the codeex company uh removing
other expenses like Sora and like their
AI for science division and then
effectively lobomizing Stargate and
switching it over to a leasing model
rather than an ownership model which if
I were CFO of OpenAI I would have been
scared to death of the ownership. model
given all of the price girrations in the
GPU market. I I would expect that given
all of those measures that open AI again
not investment advice but comes out of
all of those with a much more stable and
predictable prospectus than the open AI
that came into this year that looked
much more like a consumer play volatile
that was going to own its data centers.
Scary.
>> They they pulled it off, Alex. They
really pulled it off. They turned it
around.
They did, but that's probably what
freaked out Sarah. If you looked at the
forecast from a year ago, it it had 20
billion of ad revenue and I forget, but
many, many billions of consumer
subscription revenue and then a little
bit of enterprise.
>> And now, if you look at the forecast,
it's a complete inversion of the colors
on the bar chart. That always scares a
CFO, right?
>> Brian, you know, I have to imagine that
being a founder tech company is the big
advantage that you have over traditional
large corporations. I mean, being able
to say we're going this way uh versus
that way, but for all my friends who are
public company CF CEOs, uh it it's not
fun. How do you think about about, you
know, remembering when you were a couple
months before your IPO? What's going on
inside of a company theoretically like
this?
>> Well, a couple things come to mind. One
is um there's always there should be
some healthy tension, I think, between
like a founder, CEO, and a CFO. I mean,
that's founders are great at many
things. Um, but if you just have too
much founder energy, sometimes they blow
the place up, right? We can probably
think of our favorite companies in that
example. Um, but simultaneously, you
don't just want to have risk-minded
operators uh running the show. And that
that's just a recipe for incrementalism
or even slow decline, right? So, I think
it's sometimes the press likes to report
on these things of like, oh my gosh,
there's drama happening between, you
know, I'm like, that's called a healthy
conversation. So I imagine that they're
they're actually working like relatively
well together on this and it's a high
stakes moment for both of them.
>> Um the other thing is like sometimes
people criticize OpenAI like oh my gosh
they missed their their target uh their
end ofear target to get a billion users
or something like that and you know
internally we all we often use like the
OKR system and we we tell we tell
everybody set uncomfortably ambitious
goals and if you hit at least 70% of it
that's considered a good outcome. So
when whenever companies switch into the
public mindset, they're often setting
their goals start to become more like
appropriate for external investors where
wow, we just hit our goals every quarter
around here. Who you know? Um and so
anyway, there's a lot of t stuff like
that that happens behind the scenes. I
think the highle bit is right is what
you guys already covered is they've got
to get out just because that's what
their competitors are doing and that's
where the capital is going to all go.
So, it's going to be uncomfortable and
messy and I'm a little worried about um
these valuations where retail is going
to, you know, be the the buyer of this
and take the hit.
>> Yeah, it could be pretty choppy here.
Um, you know, just self because we
talked about how AI is sort of taking
all the oxygen out of the room. Like
selfishly, I think other techos are kind
of like, all right, finally get these
things public so there can be a real
mark on it and maybe um some of the the
hype dies down a little bit. I I also
think there's going to be fierce
competition amongst these these models
because they keep like the open source
models are basically just as good and 3
to six months behind for like 99%
>> that much if that much.
>> Yeah. And they they're like literally
99% cheaper for inference. So I think
that the demand for intelligence is
almost infinite. It probably is infinite
but the costs are going to fall like way
more than Mo's law. So um you know are
is the harness that these guys are
making whether it's codec or claude uh
claude code are those valuable? I don't
think the harness is where the value is.
I think that um like the the the
depreciation on these models like how
how fastly how fast the price of them
drop for the same level of intelligence
is going to be dramatic. And I think
within 12 18 months 80% of our workloads
are going to be going to models that are
99% cheaper.
>> Yeah. I Brian I had a meeting with a
Morgan Stanley guy right after the
Facebook IPO and he said oh my god this
was the worst disaster in in US
financial history with the stock was
down I think about half after the IPO
and nothing wrong with the company
obviously and it was a great investment
in hindsight obviously but there just
wasn't enough liquidity so they they
dumped it in all their private client
accounts then watched it go down by half
and now we're doing this three
backtoback IPOs
each one of which is a factor of 10
bigger than anything we've ever seen
before. And so I I'm just curious, the
logistics of this could be a nightmare.
Even if the companies are great and even
if five years from now they're way up
from their IPO valuations, is there
really that much money in the world?
Like does it actually exist?
>> And it'll be we'll find out, I guess.
>> Yeah. And and right now, you know, I
have a lot of friends who like if I'm
not, you know, pitching my AI story for
my company, I can't get money. AI is
sucking the oxygen out of out of the
room everywhere. All right, this next
story generally stopped me in my tracks.
Uh, you know, Google, one of the biggest
AI infrastructure players on the planet
with its own TPUs and data centers, is
paying SpaceX 11 billion per year
through 2029 to access 110,000 NVIDIA
GPUs inside of XAI's data center. Uh,
you know, SpaceX is now clearly a
hyperscaler. And it's ironic, Google is
renting compute from Elon's rocket
company, which by the way, Google is an
investor in Elon's rocket company. I
love this quote from Austin Reef who put
it. It's crazy that with one deal,
SpaceX IPO went from 100x revenues to
50x revenues. Uh, one contract have the
company's valuation multiple, you know,
and and this tells us, you know, clearly
the story. There's a massive AI compute
shortage.
>> Yeah. So
>> love to get your take on this Alex
because uh you know there was a view of
the world where Elon was building a
frontier lab with a you know
first-in-class model. Now if he rents
all the compute to Anthropic and to
Google then clearly he's backed out of
that game completely. I'm not quite sure
you know when he did the first rental to
Anthropic he said that's Colossus one.
Colossus 2 is still grinding away on the
you know the the mother of all frontier
models. You're going to actually when we
interviewed him in Austin, remember
Peter? He said that you're going to be
absolutely blown away by it was Grock 5.
>> Yeah,
>> it's it's it's brilliant. And you know,
here we are. That was due out in March
and here we are. It's June.
>> Well, he's clearly refocused his
attention.
>> Well, all of Colossus 2, do you know,
Alex?
>> I I think a lot of it uh is my
understanding. So, I I took a bit of
heat for saying a few episodes ago that
I I thought Grock in the wake of the
anthropic SpaceX deal was on life
support and Peter and I had a back and
forth with Elon on X talking about it. I
I do think Elon and SpaceX AI are going
to come back to the frontier at some
point. It's not obvious to me that the
acquisition basically the the deacto
acquisition of Curser is going to be
that moment. Uh or if that'll put them
maybe just behind the the frontier in
what effectively has become a second
tier of the frontier. Call it the Google
tier uh until Google hopefully leaprogs.
It would certainly be great to get more
competition among frontier models. But I
if if I'm Elon, I'm I'm thinking the
best shot that SpaceX AI has to get back
to being the frontier is by being a
hyperscaler first. That ultimately
algorithmic
wars, which is what we're seeing right
now, will burn themselves out. We'll
discover through recursive
self-improvement over the next few years
what a perfect AI model looks like. And
then the war, the competition moves to
who is the biggest, baddest hyperscaler,
who has the most hardware and the most
compute.
>> And Alex, don't forget the anthropic
deal can be cancelled with, you know,
some like a quarter.
>> It's month by month. I think it's month
by month.
>> And then this is only a three-year
contract. So when when Elon Elon never
uh never plays second fiddle, right? He
will be working on
>> He wrote back to us, he'll never give
up. never underline. But what I would
say is that the question is how do you
get back to the frontier? And I I
suspect the thinking may be become a
hyperscaler for the moment. Put Grock on
de facto life support for a year or two.
Use revenue from the Google deal and the
anthropic deal to accumulate enough of a
head of steam on the SpaceX side that
you're able to go and build the Dyson
swarm in sun-synchronous orbit. And then
once you have 10x 100x more compute than
everyone else, then you go and try to
reach a frontier status by training on
the
>> world and and buy every model that you
want to. He's going to have a currency
that he can go on shopping sprees with.
>> Well, he just did that with cursor, but
that may or may not be enough to get him
to the frontier. It may require
>> one of many.
>> There may be some things that money
can't buy, but that compute can. and his
thinking maybe speculatively he can buy
enough compute to buy his way back to
the frontier.
>> You know if Google needs this much
external compute like at this scale that
tells you the bottleneck has completely
shifted from model design to
infrastructure. I'm finding this hard to
comprehend that Google needs this level
of compute. That's a crazy crazy number
they're paying for this.
>> I mean I thought they had their own
infrastructure. Is that is the compute
demand so crazy?
>> Yeah. No, it's everything is sold out,
Seem. I mean, they'll take everything.
>> Yeah,
>> it's completely So, so just numerically,
this is a this is 110,000 GPUs here. I
thought he bought half a million. No, he
did the other deal with Anthropic
already.
>> Um, so does that mean he's still got a
couple hundred thousand GPUs for
internal XAI training or not?
>> I I think these are different
generations. So, the Colossus one was
sort of an unholy ad mixture of several
different I think it it was a mixture of
H100's and several other generations. Uh
so uh Colossus 2 was supposed to be a
pure mixture. Remember also Google most
of their compute takes the TPU format.
You have customers that don't
necessarily want to run their workloads
on TPUs. They may want the Nvidia CUDA
stack. And so there are variety of
reasons why if if you're Google Cloud
Platform, you want to be able to to rope
in additional GPUs if you can find them.
All right, I'm going to move us along
unless someone else has another point
you want to make here. Uh, this next
story is sort of science fiction
becoming real. I love the scope and
audacity of uh of Elon's plans. This is
their AI1 satellite they just unveiled.
The next generation AI satellite
designed, Alex, to launch humanity's
first Dyson Swarm here. The spec the
specs are wild. 150 kW of peak compute,
70 kW per ton. This is a two-tonon
satellite, a 70 m wingspan, basically
the wingspan of a an Airbus 380 with 110
square meters of deployable radiative
cooling and an integrative
micrometeorite shield. Right, there's
lots of micromedorites hitting the
planet all the time. Uh Elon's
description is worth me reading. He
says, quote, "The AI satellite is much
simpler than a Starling satellite. The
AI satellite is essentially a lot of
solar cells. You still need some laser
links, but you don't have all the super
complex antennas that you have on a
Starlink satellite. It's easier to
design than uh than the AI satellite.
It's a lot bigger. A lot of this
technology already exists with Starlink
V3. So, here he is. Uh he's making it
real. That's what he does all the time.
Build the tech to make it real. Alex,
what do you make of it?
>> A few thoughts. First, it's beautiful.
>> Yeah, it is beautiful. Second, it's so
beautiful. In in in my daily newsletter,
I featured an artistic rendering of this
design. It's beautiful. Second thought,
look at how much of its surface area has
nothing to do at all with compute. Look
at the solar arrays for power. Look at
the radiators for heat dissipation. Look
how tiny, at least by surface area. All
of this is for compute. What that says
to me is, think a few generations out.
Imagine now we're in the early 2030s and
maybe compact fusion is finally working.
Wouldn't that radically change the form
factor?
>> Power beaming.
>> Power beaming. Sure. But even with power
beaming, you still need to uh you still
need to radiate the the power from uh
from heat dissipation uh from the the
GPUs and you still need to receive the
power. uh yes, it'll enable them to be
more focused, but you're still you're
still depending on some sort of
radiative transfer in both directions.
But imagine like a few generations out,
you have some some radically innovative
radiator system to get rid of your waste
heat. And maybe you're able to locally
power yourself without needing the sun.
These can be incredibly compact. This is
the most disjointed, the largest,
bulkiest, most mainframe era node in the
Dyson swarm we're ever likely to see.
Imagine now in the future something
that's far more compact, something that
is looks maybe a little bit more
spherical and a little bit less like a
leaf blowing in the solar wind. This is
the first generation of I think the node
in our Dyson swarm Elon does over and
over again, right? his Merlin engines,
you know, V1, V2, V3, they get smaller,
more compact, get it working and then
simplify.
>> Yes,
>> Brian. Uh, any appreciation that you
want to share on this one?
>> I mean, Elon's the best in the world at
hardware. No doubt about it. I, you were
talking about micromedorites. I was just
imagining they must have some redundancy
here. Like, if if there's some bullet,
you know, some bullet fragments can fly
through this thing either on the solar
panel or on the liquid radiators. Maybe
there's different compartments like, you
know, it could it could sustain uh five
bullet hits into the radiators and still
get sufficient cooling or something like
that. And then the other thing I'm just
wondering is how does it all fold up
inside Starship? But I'm sure I'm sure
it'll be a beautiful origami. And by the
way, the point you just made about
Starship, the reason, you know, SpaceX
can do this is because of Starship and
its volume. you know, no one else I
don't think any other vehicle is going
to have the level of capacity to build
or deploy satellites like this. So,
>> but also keep in mind again so 150 kow
we were speaking previously uh with
Andrew and uh talking about cerebrus.
Cerebrus like a wafer scale engine is
what like 10 20 30 kow 20 kow
>> 20 kow. So 70 kow is a ton for this
>> versus like 20 kow for a single wafer
that's what fraction of a kilogram. So
imagine how far we are from the physical
physically efficient frontier here. When
we talk all the time on on the pod royal
we about the Dyson swarm. Some of us
talk about disassembling the moon or or
other planets and what what what a waste
by atom count most of our solar system
is. Drink. Yeah, drink.
>> What a waste by mass most of our solar
system is. If it takes an entire ton to
generate 150 kilowatts of compute in low
Earth orbit or sun-synchronous orbit,
we're orders of magnitude, but that says
to me, we're orders of magnitude away
from efficiently turning most of the
matter of our solar system, most of it
by mass anyway, into compute. So, plenty
of scaling to go as well.
>> Dave,
>> well, Peter, you're the you're the
master of launching. Uh if this is about
a $6 million GPU compute thing, you
know, 150 kilowatts is about translates
to about 6 million of GPU. But what is
the launch cost of this one unit? So
this would be equivalent to like an
NV72, you know, if it were in Nvidia
terms. That's up there in space.
>> You want to get down you want to get it
down to 100 dollars per kilogram, right?
That's the target price uh at the end of
the day. Uh and remember his original
filing was for 500,000 of these
satellites. Uh you know the calculation
is like a launch per hour of Starship 24
hours a day, 7 days a week to deploy
that and then he upped it to a million
satellites. Uh
I I I think again the audacity of his
scale is extraordinary but he backs into
the numbers as a first principal thinker
and he makes it work.
>> Yeah. A couple of thoughts here. you
know the AI infrastructure now stops
being a real estate problem and starts
becoming a launch problem right and this
is one of the moments where we're seeing
the category change in real time where
it's not a rocket company it's not a
satellite internet company it's like
literally civilizational infrastructure
company I such an unbelievable demand
for power that we have to do this and
let's remember that this was you know
data orbital compute was not in
anybody's bingo card a year ago and here
we designed it and like planning on
getting it out there. Incredible.
>> And and even more, every large AI
company is talking about putting up
their orbital data centers. Uh and now
that new Glenn is not functioning,
right? It's going to be down for at
least a year. Um maybe more. Uh SpaceX
is the only story in town. We'll see if
Relativity Space makes it happen or
Rocket Rocket Labs gets their larger
vehicle operating. Uh this next story,
you know, Elon loves building the
machines that build the machines. And
and so this week, SpaceX announced a
Gigasat factory. Love the term giga. Uh
once again, of course, in Texas, and
they're going to be producing the A1 the
AI1 satellites uh in late 2027. The
scale is enormous, 1,000 acres capacity
for 11 million square ft of facilities.
And Dave, you remember when we were with
Elon um at the Gigafactory and this is
the Gigafactory playbook once again, he
was building out again 11 million square
ft for Optimus production. Uh so the
important thing here is it's fully
integrated. You know, they're going to
produce the solar ingots, the wafers,
the solar cells, and the entire AI uh
one satellite all on one campus. Uh and
vertical integration matters. You know,
if you control the entire supply chain
from raw materials to finished products,
you control your cost and your timeline.
And that's probably the number one thing
that Elon does extremely well is
manufacturing.
>> Uh Dave,
>> is and and look at look at Texas just
running away with every one of these
projects. It's crazy.
>> Yeah. You know, and then in all the
posts online, if you look on X,
everyone's like, "Oh my gosh, he's
taking over all of Texas." Look, a
thousand acres is about two golf
courses. So next time you're flying,
look down. It's it's just two golf
courses, guys. He's not taking over all
the land in Texas. But the the impact of
this on the economy in that state is
unbelievably healthy. Unbelievably good.
So I don't know why more states aren't
competing for this.
>> I think there's an important point that
we're sleeping on, which is vertical
integration. Yeah, sure. He's he's doing
that, but it's not necessarily just for
his own sake or because he wants to be
the the master of the supply chain for
this. It's because if you follow
carefully SpaceX's announcements in
connection with its IPO, they've been
releasing demo videos, concept videos of
doing this on the moon. And if you're
not in a position to vertically
integrate production of these AI
orbiting data centers, then you're not
in a position to start manufacturing
them off the Earth, namely on the lunar
surface. So he and SpaceX released this
video of an electromagnetic slingshot
launching bam bam bam AI orbital data
centers with a rail gun from the surface
of the moon presumably manufactured on
the surface of the moon.
>> Yes. So I I think that that's the
essential thing that that we arguably
should be talking about here. If you
have vertical integration of the solar
and the compute, then you can do that on
the moon and then uh your your your
delta V is far more favorable and you
can just start slinging these things out
and building the actual Dyson swarm, not
from the Earth's surface where the
economics for heavy launch are less
favorable. Yeah. I'll never forget I was
with Elon um at SpaceX headquarters and
we were having a conversation about, you
know, the fact he was bemoning the fact
he has to make everything, right? We
we're hearing that same thing from Brett
Adcock at Figure and a lot of other
high-tech companies and there was a
product called Pika, which is the heat
shielding uh for the Dragon capsule and
he was getting screwed by the
manufacturer and so he just turned to
the manufacturer and said, "Forget it.
I'm going to make it myself and put you
out of business. And just just the
ferocious mindset he has is
extraordinary. Um
>> well, do you have a prediction, Peter?
It'd be great to get everyone's
prediction, but this partnership right
now between Daario and Elon is insanely
powerful because because you know, Alex
is pointing out continually that new
physics is going to be invented by AI
imminently. And that new physics, if it
goes right into these gigafs, uh it
could be just mind-blowing what comes
out the other side. And and also if
Daario wins the race to
self-improvement, then he's going to
have the smartest AI, you know, and
rapidly accelerating, but Elon will have
the space-based data centers and the
manufacturing capability to turn that
into a closed loop, you know, self
self-manufacturing closed loop, which
Daario hasn't even started on. You know,
there's no there's no physical stuff
going on at Anthropic at all yet. Uh,
and you know, you know, where the rubber
really hits the road is the AI that
designs chips. So here's Elon building
the Terraab, but the chip design itself
comes from the smartest AI, which is,
you know, probably going to be Daario.
May maybe, you know, OpenAI has a
chance, too. But that that duopoly
becomes incredibly powerful if they
stick together. But do you think they'll
still be friends five years?
>> Yeah, these guys, I mean, all of the
players here have formed partnerships
and broken partnerships and reshuffled
the deck, you know, probably multiple
times over the last few years. So what's
your question? Is is the partnership
going to stick together?
>> Well, five years from today, are Daario
and Elon um friends?
>> Yeah. Like like shaking hands and
>> No, I haven't seen honestly I love I
love Elon, but I haven't seen him
partner uh for the long term ever. Uh
every every partnership comes together,
he takes the lead and runs with it. I'll
register a prediction which is I I think
there are going to be such crazy things
happening in the next few years that we
we'll look back and laugh at ourselves
for even asking the question of whether
Elon will be shaking hands with
>> Dar answer to the question
>> interesting
>> questioning the question itself
thoughts
>> uh I totally agree with you Peter I
think this is like uh just I'm I'm just
boggled by the level of of somebody
thinking Looking at civilization scale
on a non-stop basis, and I love it.
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>> All right. Uh, amazing. All right, let's
move to our next story here. Let's put
some financial figures on this. Um
SpaceX valuation is uh right now in poly
market expected to hit 2.13 trillion at
the close of the first day of market. Uh
and here's the news. Morgan Stanley
projects SpaceX revenue could grow from
get this 18.7 billion in 2025. That's
the last number we have on the books to
3.4 trillion by 2040. Uh at those
revenues at 3.4 4 trillion by 2040. That
puts SpaceX's value at some place
between 50 trillion to 100 trillion.
Right? We're seeing the birth
potentially the first hundred trillion
dollar company. Uh and and these charts
down below tell the story, right? So
here's the revenue numbers today. You
know, uh Starlink is 11 billion of
revenue. Launch revenue is a measly 4
billion. Uh AI revenue from XAI at 3.2
billion. And here comes Google at 11
billion and then SpaceX uh you know
total of $18 billion. So uh crazy
numbers. Any thoughts on this? I mean I
don't think people again no no company
in history has ever hit a trillion
dollars of revenue. So just to put this
in context, you're talking about the
really really big guys like Walmart and
Amazon. You know they're getting close
but they're not at a trillion yet. Uh so
this four trillion.
>> Yeah. On the on the other hand, a
trillion is what, like 3% of US GDP. So,
and that's today's GDP. If if we undergo
his predicted uh 3xing year-over-year or
10xing year-over-year of GDP, that still
makes this a relatively small drop in
the bucket. I I think it not investment
advice obviously but I I think it is
very much a conceivable scenario and one
in which maybe the Dyson swarm gets
built and most of or a large chunk of
civilization runs on the compute that
the Dyson swarm provides. Yeah, sure. A
few trillion dollars makes total sense.
>> Seem, you want to close us out?
>> I got nothing.
>> Okay. All right. Fair.
>> I I have a question for Brian though,
just on that narrow point. So let's say
we do build the Dyson swarm. Uh let's
say uh most of the compute in our solar
system is no longer earth-based and
presumably most of our economy consists
of AI agents trading. What do you think
will be the role if any of
cryptocurrency in that future?
>> Well, I think Bitcoin will be the new
gold standard and then the payments will
be happening on chain. So um capital
formation will probably happen on chain.
borrowing and lending, you know,
that's that's the financial system that
the AI agents would end up using. So
that's the most likely outcome in my
point of view.
>> So So you think basically uh there's
almost no impact on margin regarding
whether our compute is terrestrial or
orbital on how the crypto rails or or
broader financial rails of our
civilization operate. no latency
considerations, no trust based
considerations, no decentralization
considerations like doesn't make a
difference.
>> Well, I think a lot of those things will
get better on a crypto-based system like
the decentralization characteristics,
this um soundness of money, right? Um if
you're talking about syncing up a
blockchain between multiple planets like
Mars and Earth, there would be some
delay in that. But I don't see any
reason why, you know, if you need to
transfer money between Mars and Earth,
um it couldn't happen on chain and have
a laser link between them or something
like that. And you know, um so they're
not going to be real-time payments
between those planets, but there could
be uh appropriately delayed payments. Uh
they won't need to settle as often. So
>> are these conversations you're having in
your executive committee every day?
>> My my conversations are sometimes a lot
more mundane about like how do I get
these two people to work together, you
know? But um we still got to solve all
the human problems uh before we start
building interplanetary financial
systems.
>> By the way, I have to point out, you
know, this projection by Morgan Stanley
is definitely a fundraising tool ahead
of the IPO. You know, Morgan Stanley is
one of the banks that's going to profit
from this deal. Uh there's, you know,
I'm reading every day on X that players
are opting out of SpaceX. It's
overvalued. They're valuing it at 700
million, not, you know, 1.7 trillion.
So, we're going to see. I you know I I
fundamentally believe in the long-term
value of SpaceX. Uh I just hope retail
investors don't get hit uh in the in the
process. So while we have Brian uh Brian
Longevity and Biotech, one of my
favorite stories. So first off,
congratulations on your recent raise at
New Limit, $435
million to push us towards uh age
reversal. if you don't mind, uh, tell
us, you know, origin story of New Limit
and, uh, why you and Blake started it
and what are you guys doing there?
>> Yeah. Well, actually, Jacob Kimmel and
Blake and I all started it together as
co-founders and Jacob's the CEO now, so
he's really he's brilliant.
>> He is. Um, yeah. Yeah. So, the origin
story goes actually back to the IPO of
Coinbase, believe it or not, and 2021.
Having gotten some liquidity from
Coinbase and thinking about the next 10
years and what were going to be the big
technology trends that could drive
civilizational progress, I kind of felt
like a lot of the big ones had good
teams working on it, right? AI and
fusion energy and brain machine
interfaces and all the rest space. Um,
one I one that I didn't see great teams
working on as much and that maybe seemed
underfunded was longevity. And so I I
reached out to a few folks, started
hosting some dinners um with just top
scientists and biotech CEOs and kind of
went around the table and said, "All
right, what's on the horizon that's most
exciting to you, but it's underfunded?"
And one of the folks mentioned
epigenetic reprogramming, which is this
area that talks about how you can
reprogram cells. Um Shina Yamanaka
famously won the Nobel Prize for this in
2012, showing you could reprogram an old
skin cell into a young uh embryionic
stem cell. And he by doing so with just
these four proteins added to the cell he
had this kind of remarkable discovery
that he changed both the age of the cell
and the type of the cell. So at new
limit we're trying to do half of what
Shiny Yamanaka did. We don't want to
change the type of the cell we just want
to change the age. And what we mean by
that is really just restoring the
function that the cell had when it was
younger. And um we built a uh high
throughput screening system. It starts
with AI to talk explore the you know 10
quadrillion different possibilities and
combinations of different proteins you
could use to reprogram a cell and it
starts to it it originally it ingested
all the existing literature. Now it's
been ingesting the the wet lab data
that's been coming out of New Limit
which we have the largest data set out
there by far. And so it recommends the
next set of experiments that we run in
our wet lab. We do these poolled screens
and see if phenotypically we can we can
make cells look younger. Then we take
the best hits out of that in the funnel
and we put them through functional
assays which are a little slower and
more expensive to see if they actually
act younger. Um, for instance, we might
take a reprogrammed liver cell and see
if it can process caffeine and
acetaminophen and alcohol or whatever
kind of like a young a young liver cell.
And then the the best functional assay
candidates we then are starting to run
through um non-human primate and and
human trials. So yeah, the process has
gone faster than I would have expected.
I thought this was going to be like a 5
or 10 year kind of basic research
endeavor, but um we've actually been
able to demonstrate successful
reprogramming of human cells now in our
first drug candidates going into the
clinic next year, hopefully followed by
a bunch more.
>> Amazing. Human trial next year and you
and Blake put in the first 100 million.
I remember that. I remember coming to
your lab and and seeing it. Uh full
disclosure, I'm also a shareholder, an
investor in UI. Very proud of that. So,
congrats on the progress. And uh other
news related in epigenetic reprogramming
uh Life Bioscience is another one of my
portfolio companies announced they've uh
they've dosed their first patient with
their OSK treatment today. So yes, we're
on the verge of uh longevity escape
velocity. Brian, what do you what do you
hold as a target for, you know, when do
we hit LE? Do you have a number in your
head? Do you have a a goal?
You know, man, we need Kurszswall to
come plot another curve for us, don't
we?
>> He's got his prediction. His prediction
is 2033.
>> Huh.
>> So,
>> I'd have to go look at his data on that.
I actually I haven't looked at the exact
year that it would be projected to
happen. I'm just been again trying to
solve more mundane problems like how do
we hire how do we hire the next uh you
know bioinformaticist or whatever. But
um yeah, I hope he's right. I mean, he
has been right on so many things. It
wouldn't surprise me if he's right
again. I have an idiosyncratic position.
Uh perhaps unsurprisingly, I I will go
out on a limb and say that I think LEV
is going to be spiky in the same sense
that AGI is spiky and that on certain
spikes it seems possible it might be
achieved later this year. And the reason
why I say that is and I I wrote about
this in my newsletter and I know Peter
you immediately said, "Oh, but but but
uh Uh in the past few weeks there were
uh there was a really interesting paper
published on the first uh placebo uh
rather double blinded study on HIV
patients receiving GLP1s looking at
epigenetic clocks and and I know all the
caveats. Epigenetic clocks orth style
clocks aren't uh as as good assays at
determining biological age as a variety
of functional measures. I know all of
that.
>> Okay. Nonetheless, with all of those
caveats out the way, out of the way, for
the first time, to my knowledge, in the
literature, I'm starting to see evidence
of some sort of measurable at least
double-digit age reversal as a result of
GLP1s. And that makes me ask whether as
we're we're now with Redat True Tide and
and other uh Chinese have their own I
think second and third generation GLP1s
whether we're going to start to see
hidden under our noses in the same sense
that we flew past the touring test
without remarking that AGI basically
passed the touring test. Did we with a
whimper or not with a bang whether this
year maybe next year but as soon as this
year we're going to in a spiky way in a
subpopul
fly bath fly past lev without broader
notice that it just happened.
>> Well, we're going to have some level of
proof, right? We have this $101 million
healthpan prize going on where we're
measuring functional reversal of age.
Right? Again, the biomarkers right now,
you know, you can test your biomarkers
on a whole clock and many different
clocks. The problem is if you test
yourself in the morning and test
yourself at night, you'll get different
answers. And so, I don't think there's a
reliable biioarker for aging. Brian, I
don't know if you agree with that or
not, but what I care about is less a
number on a page, but more functional.
Do you have the ability to process um
you know liver function that you did
earlier in life? Do you have the
cognition, the immune, the muscle that
you had 20 years younger? So I think
we're at the beginning of that curve and
just like in the singularity we're we're
you know living through it. I think
we're in the process and I agree GLP-1
drugs are probably one of the very first
longevity drugs out there. Brian, any
thoughts or maybe a question to Peter
and Brian on this? You think we're going
to be arguing n years from now? Let's
say it's not this year. Let's say it's
the early 2030s. We're going to be
arguing over whether we've passed LEV or
not. And we're going to bring folks onto
the pod years from now saying, "Oh, no,
it definitely hasn't been hit because my
favorite vanity benchmark hasn't been
passed yet." While others will say, "No,
it was actually passed 5 years ago."
>> Brian, I like your theory. I like your
theory on that, Alex. I I would agree
with the touring test comparison where
we probably will go past it and people
won't nobody will react. Um I I think
that's probably likely. I don't think
it'll happen this year or next year, but
um 2033 could could potentially happen.
I mean, it's like the FDA approval part
is the is the slow part, right? The AI
part is going really fast.
>> I will fly anywhere for the treatment.
>> I want to make a couple of com I want to
make a couple of comments here. Um, you
know, if you look, if we talk about LEV,
we won't know for a long time because
people won't be dying for quite a long
time. We won't really know when it's hit
except for medical certain medical
tests, etc. So, I think this is going to
drag out by definition. My favorite
comment from the life extension world is
that the baby that's going to live to a
thousand years old is already alive and
that just blows your mind.
>> Yeah. And and I agree with you, right?
The the whole basis of the la of our
health span prize was not to be a
longevity prize where you have to wait
30 years to award a winner. It's an age
reversal, right? Do you have the
function that you had earlier? You know,
one of my favorite things right now that
we haven't reported on and I'm working
to get Martin Rothblat on the pod. Um
Martine's the CEO of United
Therapeutics. Uh is work she has been
working on uh restoring your thymus. So
going from your own uh IPSC stem cells,
your induced pleot potent stem cells and
regrowing a thymus and of course you
lose your thymus in your 20s completely
and it's one of the most important
organs for regrowing. Have you been
thinking about uh about thymus uh
capabilities at new limit?
>> It's not one of the ones we've targeted
yet, but uh yeah, I think it's it's on
the list somewhere. Um we're going to
have to get to all the major tissues at
some point. I
>> I was arguing with Jacob. I want muscle
rejuvenation, please. Yeah.
>> Yeah. I mean, that would pair nicely
with the GOP ones, right?
>> For sure.
>> I want to say something I've been
wanting to say for months and months,
and I can only say on this episode,
>> which is, you know, as we talk about
life extension, there's been two things
true in the world for the history of
humanity, death and taxes. And we may,
this will crack death and Bitcoin is
going to crack taxes. So, there you go.
>> I love this tweet. I saw
>> I love it. I love it when a when a
brilliant successful entrepreneur from
outside of biotech gets into biotech
because you get that fresh view kind of
you know what is possible you know
you're not jaded you're not calloused
you're just like what is possible really
curious to know what you buy for 435
million and does it surprise you like
where that money goes
>> yeah well on the on the idea of going
into biotech I mean there's definitely
some Elon inspiration there which is
like we're we're living through a golden
age of software where fortunes are being
made And so I think the these hard tech
problems deserve more capital and you
know it's almost to like SpaceX probably
would not have existed unless some a
wealthy individual like Elon who had had
an exit had at least some of his own
capital to go try and do it. Same thing
with Tesla, right? So venture capital
sometimes doesn't get you all the way
there. It's almost like to do these real
moonshots, you have to like find someone
who made a billion dollars in software
and then and then go found step two go
found the moonshots. But I I hope that
that's not the case forever. I think a
lot of the money that's been made in
crypto and AI will actually go into the
next moonshots and and all of that
stuff. Um but sorry your question was
about um which part again? Sorry.
>> Well, 435 million you know that automate
a bunch of wet lab tests or does that
give you like concurrent many many lines
of research or what does it
>> run a human trial?
>> It's trials a lot of trials. I mean in a
software company most of your costs are
people and then some AWS and stuff like
that. Um in a biotech company typically
it's like it's people and then materials
like re like reagents and things. Um but
in this case now that we're getting
ready to go into the clinic yeah it's
you know your average phase one trial
might be I don't know 10 or 20 million
and you can kind of go up from there on
phase two and phase three. So you need
to get enough shots on goal to get some
of these candidates to come out the
other side and have a big impact. So,
we've got enough capital now to run a
number of trials, which is good.
>> Alex, I love this tweet I saw uh from
Sam Suare starting to mourn all the
people who died before the singularity.
>> Yeah,
>> I'm mourning all the the people who've
died period. And I I think you know when
to Brian's point about all of the grand
challenges that there aren't yet
billionaires solving, I think I'll throw
this out to the the universe, to the
economy. I would love to back or
otherwise support someone building a
company to use advanced compute to
digitally resurrect everyone who's ever
died. I think it's a tragedy that we've
had so many billions of deaths over the
millennia. Let's fix it.
>> I love that. I love that. All right. Our
next story here is a fun one. Our last
three stories in the field. Uh Columbia
University researchers successfully
edited a PCSK9 gene. This is, you know,
your LDL, your bad cholesterol and an
HBG gene for hemoglobin in embryos in
vitro. So, uh, you know, this is opening
up the conversation. I remember when I
was, uh, uh, at the Whitehead Institute
doing my medical degree, uh, and the
first gene editing capabilities of
restriction enzymes came out. a lot of
hand ringing around uh embryo editing,
zygote editing. You know, 2018, a
scientist in China uh Hi Janu uh
successfully edited the CCR5 gene in two
young girls that were brought to term
healthy uh to make HIV resistance. So
the question is, are we going to start,
you know, when this gets reliable
enough, are we going to start editing
our kids? Um, you know, my son Dax just
did a project on this at school and his
point was we give our kids the best
food, the best education, the best
friends, the best clothing. Why not
start with the best jeans? So, I am
curious uh what your thoughts are guys.
>> Yes, of course. Like this is this is
much more advanced than even Gatka. The
whole plot of Gatka was it's it's still
your genes, your parents' genes, just
the best combination with extreme in
vitro selection of embryos. This goes
beyond this to to do base editing of
embryos. And you know, base editing
itself is is looking tremendously
promising, invented by David Louu and a
collaborator at Harvard. Better than
first generation crisper. you're able to
to do uh single nucleotide swaps uh in
in DNA with minimal error rates. This is
tremendous and I I can't for the life of
me understand or otherwise why this
wouldn't become a broadspread practice.
Yeah, obviously uh you know, shadows of
eugenics come to mind, but at the end of
the day, if you're getting rid of
hereditary disease or if you've got
some, you know, if you're a family below
5 foot and you want your kids to be
taller, uh you know, the ethics of this
are going to evolve and morality around
this is going to evolve and societal
norms are going to evolve. Seem, where
do you come out on this?
>> Well, two things. One is this is going
to have a a lot of people freak out. But
let's note that we have an old word for
all this is called breeding. For
thousands of years, we've been crossing
dogs and cats and horses and humans to
select the traits that we want. What's
happening now is biology is becoming a
digital programmable domain. Disease
prevention is the most compelling case
here. But the governance things that
this will bring up are going to be
unbelievable because we're going to be
editing diseases like right before birth
at this point. I said this is incredible
between uh sequencing crisper IBF AI
modeling like anything is now possible
just think of yourself your 50 trillion
cells for every human being in the world
is now a software engineering problem.
How do we think about that?
>> Brian.
>> Yeah. Well, I think one of the one of
the bigger
>> please
>> problems with this particular one of the
bigger complexities is jurisdiction. So
that if you're if you live in a country,
so suppose your parents are in the US
and you go to a a Caribbean island and
that Caribbean island is say, "Yeah, do
whatever you want." Um, so then you've
got a baby, you then you bring that baby
back in the US. That's inevitably going
to happen. So regardless of what your
local laws decide they would like it to
be, it's not going to actually work
locally. So that that's a really big
complexity in this whole this whole
area.
>> Brian, you want to weigh in?
>> Yeah, it's a great point. I mean, I I
think this is going to happen, too. I
think it'll be good for humanity um on
net. I think a lot of people will freak
out about it for a while, but it's I
think there was a Pew Research study I
saw that something like 80% of Americans
would support um embryo editing for
disease prevention. So, that was more
than I expected. I thought 80% is pretty
high, but you know, only about 20% I
think supported it for quote
enhancement. Um the part that I've never
been able to figure out is what's the
line between disease prevention and
enhancement, right? Um not having a
disease sounds like a pretty good
enhancement to me. I mean there's
there's cases where like let's say
osteoporosis, right? So if you have
that, it's a disease. But if you had a
gen a gene edited to prevent it, you
have stronger bones. Stronger bones
sounds like an enhancement. I I
basically think the line is so blurry
that
>> people will start with this for disease
prevention and then it'll uh upgrade
over time. And I think anything's, you
know, on the table, even IQ or whatever.
It's like, should we have more smart
people in the world? Probably. I mean,
that's seems like a good thing to me.
>> And ethics change, right? Because I
mean, if you remember a while ago, IVF
was considered immoral in the early
days.
>> And now it's it's enabled millions of
families to be formed.
>> Well, but not to state the obvious, but
uh you know, if you're 7 foot tall or
higher, you have a 50% chance of making
the NBA. And if you make the NBA, that's
a $20 million a year paycheck. So if
you're a couple, you know, just a
regular everyday couple in the US and
you have the option to have a 7 foot
long tall child by design, you're going
to go to that Caribbean island and make
your seven foot tall for economic
reasons. How, you know, think of what
could go wrong then.
>> So there there's going to be some
serious guardrails. There has to be
guardrails around this.
>> You know, there's a company I love uh
called Nucleus. Uh Ken Sedagi, the CEO,
is going to be at my my abundance
longevity trip in October. Uh Brian, I'm
I'm hoping to have uh someone from
Uliimmit there as well. But what nucleus
does is you fertilize, you know, 20 uh
20 eggs, you know, 20 zygot and then you
sequence them and you can choose the one
out of the 20 that have the attributes
instead of playing dice and wait, you
know, and hoping for the lucky sperm. Uh
you can actually pick the one that has,
you know, the right attributes from
within the gene population that you
have. Separate from base editing, a step
before that, but still something you can
do today. Remember the line from Gatka,
"Your child is still you, simply the
best of you,
>> except that's not even true with base
editing. It's better than the best of
the parents."
>> Well, Brian, listen, thank you for
joining us today. Uh, grateful. I know
you've got, you know, the world's
largest, uh, crypto company in the world
to to run. So, uh, appreciate your time,
my friend.
>> Yeah, thank you for having me. This was
a great conversation. I love talking
with people who want to build a future.
>> Yeah, for sure. And that is most
definitely this this amazing group. All
right. Uh our next story here is
Anthropic launches Fable 5 and Mythos 5.
Uh here we go. Uh Andre Kaparthy uh who
has joined uh our friends at Anthropic
is now shilling for the newest models.
Here's his quote. Super exciting
release. Fable 5 is the same underlying
model as Mythos, but with added
safeguards. You can 10x your test suite,
autooptimize code, run giant research
projects with custom HTML for the
results, anything. Alex, over to you.
>> Very impressive release. Anthropic is
back in the lead now. Uh, until today,
GPT 5.5 was the lead, the
state-of-the-art across most of these
benchmarks. today for probably about 5
minutes. Anthropic takes back the crown
across most measures of super
intelligence. A few notes. The
distinction between Fable 5 versus
Mythos 5. Mythos is a uh as reported a
less inhibited version of Fable. Or
conversely, Fable is a more inhibited
version of mythos that has certain
scaffolding and other restrictions that
prevent it from having more ambitious
conversations that might relate to
biology, chemistry, cyber security,
perhaps other areas. But I've used it.
It's incredible. I gave it my typical
benchmark, which is favorite eval,
asking it to oneshot a cyberpunk
FT first person shooter that's visually
stunning. Did an amazing job, no errors,
ran immediately, had a nice soundtrack
that came with it. What's more
interesting if you look at the
benchmarks and then also the
demonstrations far be it for me to
suggest that Pokemon games are actually
the secret to super intelligence but if
you look at the demos that have been
coming out from anthropic and otherwise
it is able to play just from pure visual
reasoning now this is Fable 5 or mythos
5 doesn't really seem to matter it's
able to based on just watching the
screens of games like various Pokémon
games it's able to win them and that
requires long-term long range reasoning
capabilities that we really haven't seen
until now. So my guess is Anthropic has
probably been very aggressively doing
RLVR reinforcement learning with
verifiable rewards on long range
reasoning challenges. maybe game
playing, maybe challenges that involve
spatial reasoning, maybe very large code
bases, maybe very large capture the flag
CTF hunts, very large sprawling both in
probably, my guess would be in space and
in time RLVR challenges to get some of
these results that it's just incredible
what you can oneshot now with Fable 5 uh
with reasoning set to high. And again,
difficult to predict how long Anthropic
will retain the crown before, say, GPT
5.6 comes out, but it is exciting to see
the Frontier move once again.
>> Dave, you've been playing?
>> Yeah. Well, it's only been out for about
4 hours, but I've been playing for 4
hours, so uh it's I mean, what we're
living through, Alex is constantly
posting on our internal feed. It's
happening. It's happening. I mean, it's
really happening now. This is Oh my god.
You know what's interesting to me? a
bunch of things. First of all, they
doubled the price, so it's expensive as
all hell. Uh this this idea of commodity
intelligence is not happening. It's it's
damn expensive if you want the most
brilliant thing. But what it produces is
so incredibly intelligent that it takes
you quite a while to read and understand
what it did. And it's like, well, I'll
just move on while you're reading and
trying to catch up.
>> And so that's an interesting new thing
for me. Um, and also I think this is
interesting that Anthropic had it in the
bag. You know, Alex just mentioned that,
you know, the leap frog is going on, but
actually OpenAI pushed out their best
and Anthropic then said, "Okay, well, we
had this ready to go." So, you know,
we're just trying to make it safer, but
now we'll come out and go over the top.
>> And we've been saying they're they're
pulling their punches. They're they are
they're they're gaming this.
>> Uh, as you're heading towards your
flight, do you want to add anything
here?
Uh, no. What occurred to me here is
that, you know, when you have you have
the um split now between the safety
guard rails and the performance guard
rails. And I thought that was really
interesting
because you've got the same underlying
model with added safeguards, right?
That's the whole safety debate in one
sentence right there.
>> Well, actually, they even changed the
name, too. You know, you've got the the
Mythos, which we've been talking about
for a while, and then Fable is the
heavily guardrailed, won't do a cyber
threat, won't do a nuclear weapon, you
know, version of the exact same model.
Uh so they even even differentiated it
by name to support exactly what you're
saying. lame
>> with with pretty broad buffers like you
can friends of mine have tried having
conversations perfectly innocent
conversations with fable five high about
biology and from what I've heard it has
pretty broad margins for what it will
simply revert back to opus for if if it
thinks you're asking anything in biology
or chemistry that could remotely be a
dangerous subject it'll just downgrade
you immediately to opus
>> you know funny you say that Alex cuz uh
you know I'm often trying to work from a
plane and SSH doesn't work on the plane
Wi-Fi and and so I, you know, use a
workaround to try and get access to all
my remote agents. And that also vomited
saying looks a little bit like maybe
you're doing something sketchy and it
gave me the uh the anthropic, you know,
we're we're not going to answer that
query thing, you know, repeatedly. So, I
had to actually find a workaround for
that, too. So yeah, they've really
really locked it down to try and avoid
the
>> I predict as we head towards IPO season
for these two companies, these Frontier
Labs, we're going to start to see the
rate of model release increase. They're
going to be leaprogging who's going to
be out front at the day of the IPO.
Who's getting the news?
>> At least at least, Peter, we have
competition. The situation could be
worse. We could just have a singleton, a
single lab that is that is not getting
leaprogged at all. At least we have two
competitors at the moment in the lead.
>> Yeah, for sure. All right, our final
story for today. Uh, after more than a
decade of sucking, Apple finally made
its move to improve Siri. Uh, they've
announced a multi-year partnership with
Google to power Siri with Gemini AI,
rebuilding Siri from the ground up. Uh,
the big shift, Siri is now an agent, not
just a voice interface. The key
breakthrough is personal context. Yes,
finally. Siri can now reason across your
messages, your emails, your notes, your
photos, and actually get things done.
And it can actually, you know, when I'm
sending a text message to Kristen, it
can spell it correctly or it can spell
my name, you know, correctly. It doesn't
most of the time. Uh they're calling it
persistent AI workspace coming to beta
later this year. Uh focused in English.
Uh two huge implications here. First,
Apple is essentially admitting it lost
the Frontier model or the foundation
model race and chose Google to rent
brains rather than build its own. And
and it's a stunning, you know,
concession from the company that has
always priding itself on its own stack.
Second, the real emote was never the
model. It's the personal context. So,
uh, Alex, you wanna you want to share?
>> I'll different perspectives here. So one
the glass half empty perspective is
Apple for arguably the first time in
modern history has has outsourced an a
key element of its tech stack which
Apple it it's just not as with Elon and
vertical integration. It's not in
Apple's cultural DNA to to want to rent
out someone else's technology that's
going to be so core to the system.
That's the glass half empty. second
perspective and that perspective says
the foundation model is not analogous to
say an operating system. It's more
analogous to the role of a search engine
which has to be localized. So you'll
note Apple didn't announce this in China
yet. It didn't announce it in the EU yet
for different reasons. But focusing just
on China, I would expect Apple to strike
some partnership that's roughly
analogous to the partnership with Google
with one of the three big Chinese AI
labs or tech companies. And that will
represent a localization roughly
analogous to the way Apple localizes its
other web search capabilities in China
with one of the Chinese companies
analogously to the way it default uh to
Google for web search. to the glass half
full argument is well foundation models
however foundational they are are
intrinsically localizable and so Apple
has merely chosen for its American
franchise Google and maybe it'll choose
another franchisee for Europe and
another one for China
Google's been doing this with Android
and its suite of products for a while
now right so this is Apple sort of
catching up I mean I've almost you moved
to an Android phone so many times just
because of its ability to, you know,
contextualize all of my my personal
context.
>> A third perspective. Yes. And a third
perspective is if you buy that
foundation model economics are
hyperdelationary and are the cost is
going down by 40x year-over-year or
anything remotely like that, then you
should view this entire bit of Apple
losing its tech sovereignty as a nothing
burger. And yes, Apple maybe is is
struggling to distill Gemini down to its
private cloud compute combined with
iPhones this year, but in a year or two,
there will have been so much
hyperdelation in the cost of compute
that for the present capabilities of new
Siri that they will easily fit into the
new iPhones. and that any loss of
sovereignty or any use, we haven't even
touched on this semi- embarrassingly.
It's not even the case that Apple is
just able to distill Gemini, Google's
Gemini or its version thereof into the
iPhones. And it's not even the case that
they're able to operate it with a
combination of Apple's own cloud
combined with the the iPhone edge
compute. They actually need Google's
cloud to do this because it's so comput
intensive. But all of that over the next
year or two can shrink and hyperdelate
down to to just working on an edge
device as these algorithms get more
advanced.
>> Yeah. Dave, any thoughts on Apple?
>> Yeah, lots. Well, anytime in tech that
you don't do anything for a long period
of time, you eventually get crushed. The
question is how does it emerge? The way
it would play out if Apple doesn't do
something aggressive uh is you lose the
interface. You know, Siri is now Google,
but Google is Android and Android is the
one competitor to the iPhone. Remember,
all the revenue still comes from the
iPhone. So, you lose the interface. At
the same time, TSMC
moves the chip manufacturing away from
the M5 and M3 and M4 to a much higher
paying customer in AI data center use.
So Nvidia or Elon take the manufacturing
capacity away for the underlying chip
because they just pay more to TSMC. So
then you've lost your hardware
manufacturing under the covers and
you've lost the interface on the other
side and then everybody just moves to
Android because they're talking to
Google or Gemini all day long anyway.
And so also the machines get the the
actual physical phones get manufactured
by Samsung using Samsung's uh chip
manufacturing capability which is you
know immune to TSMC.
>> Selma I want to acknowledge your
persistence and your ability to stay in
the conversation.
>> This is a new low. I'm in my airplane
seat. So let's just let it just go past
us.
>> Okay. Closing closing thoughts on Apple
and uh and Siri.
>> Your closing thought that it's good.
I'll believe that it's good when I see
it.
>> Yeah, we've been so disappointed over
and over again. I you know, you and I
met the founders of Siri before they
sold to Apple. Uh and it was it prom it
had such promise back then and it just
uh it stuck around just way too long. Uh
gentlemen, uh I think that's a wrap.
Enjoyed having Brian here going from
Bitcoin to longevity. Um anyway, uh
crazy week ahead. I I'll see you guys in
a few day for our next episode. Uh,
thank you as always for your commitment
to this podcast. Everybody watching,
thank you for your, you know, support of
Moonshots. We're here to give you the
news, help you understand it, help you
be optimistic. Uh, it is the most
extraordinary time ever to be alive. I
like to say, you know, during the
singularity, don't sleep, don't blink.
Uh,
>> the words live long, the words live long
and prosper.
>> Yeah, they do.
Take care, gentlemen. Safe travels
everybody.
>> Peace and long life.
>> Take care folks.
>> If you made it to the end of this
episode, which you obviously did, I
consider you a moonshot mate. Every
week, my moonshot mates and I spend a
lot of energy and time to really deliver
you the news that matters. If you're a
subscriber, thank you. If you're not a
subscriber yet, please consider
subscribing so you get the news as it
comes out. I also want to invite you to
join me on my weekly newsletter called
Metatrens. I have a research team. You
may not know this, but we spend the
entire week looking at the meta trends
that are impacting your family, your
company, your industry, your nation. And
I put this into a two-minute read every
week. If you'd like to get access to the
Metatrends newsletter every week, go to
diamandis.com/tatrends.
That's diamandis.com/metatrends.
Thank you again for joining us today.
It's a blast for us to put this together
every week.
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