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How the Novel Coronavirus Infects a Cell: Science, Simplified

1:40EnglishBy Scripps ResearchTranscribed Jul 27, 2026
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0:04

Due to its unique features, the novel coronavirus  is particularly good at infecting new cells  

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both in the upper respiratory tract  as well as deeper down in the lungs.  

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Here's a look at how the process takes place. The  microscopic virus enters through the nose or mouth  

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where it begins its infection of our airways. The  outer spike protein of the coronavirus latches  

0:26

onto specific receptors on the surface of cells  in our respiratory tract. In the case of COVID19  

0:31

the virus latches on to the ACE-2 receptor.  This binding triggers the process by which the  

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virus fuses into human cells. The viral envelope  merges with the oily membrane of our own cells  

0:43

allowing the virus to release its genetic material  into the inside of the healthy cell. The genetic  

0:48

blueprint of the virus is RNA instead of DNA which  acts as a molecular message, instructing our host  

0:54

cell machinery to read the template and translate  it into proteins that make up new virus particles.  

1:01

The hijacking persists as the human host cell  continues to generate more copies of the virus,  

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assemble these copies into viable particles,  and traffic them to the outer edges of the cell  

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for release. Each infected cell may  produce and release millions of copies  

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of the virus which can then go on to infect other  neighboring cells as well as neighboring people  

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when they are expelled from the airways  in droplets via coughing and sneezing.

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